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Evaluation of Cardioprotective Potential of Hydroalcoholic Leaf Extract of Citrullus colocynthis against Doxorubicin Induced Oxidative Stress in Rats

Evaluation of Cardioprotective Potential of Hydroalcoholic Leaf Extract of Citrullus colocynthis against Doxorubicin Induced Oxidative Stress in Rats

Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5

1Fatima-Tu-Zahra, Department of Life Sciences Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan
2Department of Pharmacology, The Islamia University of Bahawalpur, Bahawalpur
3Ali-Ul-Murtaza, Department of Rehabilitation Sciences, Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan
4Department of Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, Ocean University of China, China
5Department of Pharmacology and Toxicology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
 
* Corresponding author: imranahmadkhandurrani@gmail.com

ABSTRACT

To evaluate the cardioprotective potential of hydroalcoholic leaf extract of Citrullus colocynthis against doxorubicin-induced myocardial ischemia in rats. Animals were divided into 5-groups each group consisting eight rats. Group-1 was given saline for 2 weeks and on 11th day DOX 18mg/kg was given intraperitoneally. Group-2, Group-3, Group-4 rats pre-treated orally with the leaf extract of C. colocynthis 250mg/kg, 500mg/kg, 750mg/kg respectively for 14 successive days and on 11th-day DOX was inoculated, while group-5 was used as positive control and was given dexrazoxane 180mg/kg after 30 min DOX was given. The levels of CK-MB, LDH, troponin-I, AST, CRP, ALT, and ALP were estimated in all5-groups and compared. Histopathology was conducted to examine the status of cardio myocytes. Pretreatment of rats with leaf extract had a cardio protective effect and significantly reduces the biochemical parameters against doxorubicin-induced myocardial damage in dose-dependent manner. The cardiac tissues showed marked improvement in extract treated groups as compared to doxorubicin treated group. This research indicates that the hydro alcoholic leaf extract of C. colocynthis have exceptional cardio protective potential as compared to toxicity induced by DOX. As a result, it could be used as an alternative medicine for the treatment of cardiovascular disorders.

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Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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