The study was conducted to ascertain the hospital prevalence of buffalo diseases and to determine the temporal distribution of important infectious diseases of buffalo like as Foot and Mouth Disease (FMD) and Haemorrhagic Septicaemia (HS) at Upazila veterinary hospitals of Jaintapur, Gowainghat and Kanaighat upazilas of Sylhet district. From October, 2015 to September, 2017 a total of 1057 cases of buffalo diseases were recorded in the hospital record books. Among all diseases, the overall hospital prevalence of Helminthiasis in buffalo was highest (22.32%) followed by FMD (20.71%; 95% CI: 18.38%-23.27%) and HS (10.78%; 95% CI: 9.06%-12.80%). Prevalence of FMD was found significantly higher in Jaintapur (26.75%) than rest two Upazilas. Highest prevalence of FMD (36.08%) was observed at young animal (above 2-4 years) followed by Adults (15.10%) and calf (5.60%). Epidemic curves using the information of weekly occurrence of FMD showed consistent occurrence of this disease round the year with peaks during winter season. Similar analysis was also done for HS and like FMD, highest prevalence (16.14%) found in Jaintapur upazila. HS prevalence also found significantly higher in young buffalos (18.56%). HS prevalence was significantly higher in male (12.73%) than female. Epidemic curves of HS showed a clear year round occurrence with peaks in summer season. Though, estimates could not expressed real disease burden because of using information of hospital register, outcome of this report provided some hints of burden and identified some potential factors and temporal trend of FMD and HS in buffalos of selected upazilas of Sylhet.