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Effects of Oral Glucose Administration on Plasma Biochemical Parameters, Insulin, and Hepatic Metabolic Enzymes Activities in Golden Pompano (Trachinotus ovatus)

Effects of Oral Glucose Administration on Plasma Biochemical Parameters, Insulin, and Hepatic Metabolic Enzymes Activities in Golden Pompano (Trachinotus ovatus)

Chuanpeng Zhou1, Heizhao Lin2,*, Zhong Huang2, Jun Wang1, Yun Wang1 and Wei Yu2

1Key Laboratory of Aquatic Product Processing, Ministry of Agriculture, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China
2Shenzhen Base of South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shenzhen 518121, PR China

*      Corresponding author: linheizhao@163.com

 

ABSTRACT

Two doses of glucose (335 and 1670 mg of glucose per kg body weight) were orally administered to golden pompano (Trachinotus ovatus). Plasma glucose and cholesterol level reached its peak 3h after oral administration with high dose of glucose, respectively (P<0.05). Plasma insulin content was significantly lower at 1, 3, 6 and 12 h after oral administration of both doses of glucose (P<0.05). Compared to the low dose of glucose group, the high dose of glucose group has lower plasma glucagon content 12 h after oral administration, higher muscle and hepatic glycogen contents 6 h after oral administration (P<0.05). The hepatic pyruvate kinase activity peaked 6 h after oral administration in both doses of glucose groups and thereafter started to decrease 24 h after oral administration. While the hepatic PEPCK and G6Pase activities decreased 9 h after oral administration in both doses of glucose groups and then returned to the level at 0 h (P<0.05). These results suggested that glucose oral administration resulted in prolonged hyperglycemia and high level of hepatic glycogen in T. ovatus which could lead to nutritional stress, and increasing glucose metabolic burden in this species. 

 

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Pakistan Journal of Zoology

June

Vol. 53, Iss. 3, Pages 801-1200

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