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Effects of Moringa oleifera, Curcumin, and Green Tea Extracts on Histopathological Changes in Mesenteric Lymph Nodes and Spleen of Albino Rats with Benzene-Induced Leukemia

Effects of Moringa oleifera, Curcumin, and Green Tea Extracts on Histopathological Changes in Mesenteric Lymph Nodes and Spleen of Albino Rats with Benzene-Induced Leukemia

Ahmed Alazzouni1, Ashraf Al-Brakati2,*, Sherif Rabie1, Mohamed Gabry1 and Basmaa Hassan1

1Department of Zoology and Entomology, Faculty of Science, Helwan University, Helwan, Cairo Governorate 11111, Egypt
2Department of Human Anatomy, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
 
* Corresponding author: a.albrakati@tu.edu.sa

ABSTRACT

This study evaluated the protective effect of Moringa oleifera, curcumin, and green tea extracts against benzene chromasolv-induced leukaemia in rats and their ability to alleviate the histopathological alterations in the mesenteric lymph nodes (MLNs) and spleen. In this study 70 rats were divided into seven groups as follow: control, benzene (0.2 ml twice/week), Moringa oleifera (100 mg/kg), curcumin (300 mg/kg), green tea (350 mg/kg), combined green tea and curcumin, and cyclophosphamide (7.5 mg/kg) groups. All groups were treated for one month after the induction of leukemia. We found that the extracts ameliorated most histopathological changes in MLNs and spleens in rats exposed to benzene, restoring normal mast cell counts and elastic fiber area percent in a benzene-induced leukaemia model. To conclude Moringa oleifera, curcumin, and green tea extracts could be used as natural chemotherapeutic agents and as adjuvants to ameliorate histopathological changes associated with leukemia.

 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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