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Effect of Total Phenolic Acid on the Repeated Cerebral Ischemia-Reperfusion Model in Mice

Effect of Total Phenolic Acid on the Repeated Cerebral Ischemia-Reperfusion Model in Mice

Mingsan Miao*, Hui Zhao, Jiaojiao Jia, Xiaoyan Fang and Yanyan Miao

College of Postgraduates, Henan University of Chinese Medicine, Zhengzhou 450046, China

*      Corresponding author: miaomingsan@163.com

 

Fig. 1.

Effect of pathological changes in brain cortex of mice with repeated cerebral ischemia-reperfusion (HE×400). a. Blank Group; b. Model Group; c. Nimodipine Group; d. Naoluotong Group; e. High-dose Spatholobus Grandiflprum Group; f. Mid-dose Spatholobus Grandiflprum Group; g. Low-dose Spatholobus Grandiflprum Group.

Fig. 2.

Effect of pathological changes in the cortex of brain tissue of mice with repeated cerebral ischemia-reperfusion. a: Cerebral cortical nerve cells are normal; b: Cerebral cortical individual nerve cell edema, individual neuron degeneration, cytoplasm light staining, fuzzy structure, individual neuron necrosis; c: Cerebral cortex a small number of nerve cell edema, scattered, a small number of neuronal degeneration The cytoplasm is lightly stained and the structure is fuzzy; d: Cerebral cortical nerve cells edema, most of the neurons are necrotic; A: Blank Group; B: Model Group; C: Nimodipine Group; D: Naoluotong Group; E: High-dose Spatholobus Grandiflprum Group; F: Mid-dose Spatholobus Grandiflprum Group; G: Low-dose Spatholobus Grandiflprum Group; -: Cerebral cortical nerve cells are normal; +: Cerebral cortical individual nerve cell edema, individual neuron degeneration, cytoplasm light staining, fuzzy structure, individual neuron necrosis; ++: Cerebral cortex a small number of nerve cell edema, scattered, a small number of neuronal degeneration The cytoplasm is lightly stained and the structure is fuzzy; +++: Cerebral cortical nerve cells edema, most of the neurons are necrotic.

Fig. 3.

Effect of pathological changes in hippocampus of mice with repeated cerebral ischemia-reperfusion model (HE×400)

Fig. 4.

Effect of pathological changes in hippocampus of mice with repeated cerebral ischemia-reperfusion model; A: Blank Group; B: Model Group; C: Nimodipine Group; D: Naoluotong Group; E: High-dose Spatholobus Grandiflprum Group; F: Mid-dose Spatholobus Grandiflprum Group; G: Low-dose Spatholobus Grandiflprum Group; -: Brain cells in the hippocampus are normal; +: brain hippocampus, individual nerve cells edema, scattered, individual neuron degeneration, cytoplasm lightly stained, fuzzy structure; ++: a few hippocampal edema in the hippocampus of the brain, a few neuron degeneration, cytoplasm Light staining, fuzzy structure; ++: cerebral hippocampal neuronal edema, most of the neuron necrosis.

Pakistan Journal of Zoology

June

Vol. 52, Iss. 3, Pages 825-1224

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