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Effect of Quercetin on Rhinitis via Inflammatory Pathway

Effect of Quercetin on Rhinitis via Inflammatory Pathway

Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu* 

Otolaryngology Head and Neck Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No. 555 Youyi East Road, Beilin District, Xi’an City, Shaanxi Province,710054, China

*      Corresponding author: luckydog0730@sina.com

Fig. 1.

The effect of qurecetin and montelukast on sneezing, nasal rubbing and nasal redness in OVA induced allergic rhinitis in rats. A, sneezing; B, nasal rubbing; C, nasal redness. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.

Fig. 2.

The effect of quercetin and montelukast on biochemical parameter and spleen weight in OVA induced allergic rhinitis in rats. A, NO; B, histamine; C, spleen weight. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.

Fig. 3.

The effect of quercetin and montelukast on pro-inflammatory cytokines and inflammatory mediators in OVA induced allergic rhinitis in rats. A, IL-6; B, INF-γ; C, IL-4; D, IgE. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.

Fig. 4.

The effect of quercetin and montelukast on pro-inflammatory cytokines and inflammatory mediators in OVA induced allergic rhinitis in rats. A, IL-6; B, IL-10; C, INF-ϒ; D, IgE. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.

Fig. 5.

The effect of quercetin and montelukast on mRNA expression of pro-inflammatory cytokines in OVA induced allergic rhinitis in rats. A, TNF-α; B, IL-1β; C, IL-10; D, INF-ϒ. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.

Pakistan Journal of Zoology

February

Vol. 53, Iss. 1, Pages 1-400

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