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Effect of Variable Kisspeptin Doses on Prostatic Citric Acid Levels in Male Mice

Effect of Variable Kisspeptin Doses on Prostatic Citric Acid Levels in Male Mice

Faiqah Ramzan*1 and Muhammad Haris Ramzan2

1Gomal Centre of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Khyber Pakhtukhwa, Pakistan
2Department of Physiology, Khyber Medical University Institute of Medical Sciences, Kohat, Khyber Pakhtunkhwa, Pakistan 

        Corresponding author: faiqah_ramzan@yahoo.com 

 

ABSTRACT

 Kisspeptin, a product of the KISS1 gene, plays an essential role in the regulation of spermatogenesis acting primarily at the hypothalamic level of the gonadotropic axis. Citric acid is synthesized and secreted by the prostate gland. Its synthesis is regulated by androgens. As, dose dependent degeneration of prostate gland has been described following intraperitoneal kisspeptin treatment. However, effects of kisspeptin administration on the levels of prostatic citric acid remain elusive till date. The present study, therefore, addresses the effects of 12 day administration of kisspeptin on prostatic citric acid levels in male mice. Kisspeptin-10 was administered intraperitoneally in different dosage concentrations (1μg, 1 ng, and 10 ρg) to adult male mice twice daily for 12 days. Prostatic citric acid levels were determined photometrically. The levels decreased significantly at all tested doses. Intermittent administration of Kisspeptin –10 negatively regulates the prostatic citric acid levels in adult male mice.

 

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Pakistan Journal of Zoology

December

Vol. 51, Iss. 6, Pages 1999-2399

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