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Effect of 25(OH)D3 Supplementation in Sows’ Diets on Heart Development in Neonatal Piglets

Effect of 25(OH)D3 Supplementation in Sows’ Diets on Heart Development in Neonatal Piglets

Qingyue Han1, Ying Li1, Jichang Deng1, Kunxuan Huang1, Yanyang Yang1, Quanwei Li1, Zhuowei Zhang1, Na Qiao1, Yanju Ji2, Khalid Mehmood3, Sarfaraz Ali Fazlani4, Hui Zhang1 and Zhaoxin Tang1*

1College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. 
2Huizhou Engineering Vocational College, Huizhou, China.
3Faculty of Veterinary and Animal Sciences, Islamia University of Bahawalpur, Bahawalpur
4Lasbela University of Agriculture Water and Marine Sciences, Uthal, Balochistan
 
* Corresponding author: tangzx@scau.edu.cn

ABSTRACT

The 25-hydroxyvitamin D [25(OH)D] level in serum is currently considered the best indicator of vitamin D supply to the body from cutaneous synthesis and nutritional intake. Few reports are available regarding the effects of vitamin D and its metabolites on heart development in swine. The effect of 25(OH)D3 and Ca2+ supplementation in diets on heart development in neonatal piglets during pregnancy were examined in this study. Total 40 sows of 7 gestational age with good health and nutritional condition were divided into four groups (n=10): the control group, low calcium, 25(OH)D3 group and low calcium with 25(OH)D3 group. Each groups consist of 5 piglets, randomly selected and euthanized within 2 h after birth. After euthanasia, heart was collected for histopathological examination and IGF, IGF1, IGF2, IGFBP3, PCNA and ki67 expression were analyzed. The results showed that low calcium supplementation decreased the cardiac index and development of myocardial muscle fiber, while vitamins D3 can improve the decrease of cardiac index and development of myocardial fiber due to low calcium supplementation. The expression profile of IGF1, IGF2, IGFBP3, PCNA and ki67 genes were down regulated in LCa group as compared to control group; while the vitamin D3 supplementation significantly up regulated the above genes expression. In conclusion, our findings suggested that 25(OH)D3 and Ca2+ supplementation in sows’ diets has an important role in the development of heart and differentiation of myocardial fibers in neonatal piglets by changing the expression of the IGF pathway and myocardial cells proliferation.

 

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Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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