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Effect of Homoharringtonine on Proliferation and Apoptosis of Osteosarcoma Cells via LINC00857/miR-340

Effect of Homoharringtonine on Proliferation and Apoptosis of Osteosarcoma Cells via LINC00857/miR-340

Junli Liu1, Tongfang Yang2 and Lisheng Wu3*

1Second Department of Orthopaedics, Affiliated Hospital of Shandong Medical College, Linyi, 276000, China
2Department of Orthopaedics, Affiliated Hospital of Shandong Medical College, Linyi, 276000, China
3Traumatology Department, Beicheng New Area Hospital of Linyi People’s Hospital, Linyi, 276000, China

*      Corresponding author: 15065959569@163.com

Fig. 1.

Effect of homoharringtonine on P21 protein expression in U2OS cells

Fig. 2

Effect of homoharringtonine on U2OS apoptosis and Caspase-3 protein expression.

Fig. 3

Overexpression of LINC00857 can alleviate the effects of homoharringtonine on U2OS apoptosis as well as P21 and Caspase-3 protein expressions

Fig. 4.

LINC00857 targets miR-340

Fig. 5.

Inhibition of miR-340 can alleviate the effects of homoharringtonine on U2OS apoptosis and P21, Caspase-3 protein expression.

Fig. 3

Overexpression of LINC00857 can alleviate the effects of homoharringtonine on U2OS apoptosis as well as P21 and Caspase-3 protein expressions

 

Pakistan Journal of Zoology

February

Vol. 54, Iss. 1, Pages 1-501

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