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Effect of Extended Window Thrombectomy on Acute Cerebral Infarction and Granulocyte Colony-Stimulating Factor Expression and Postoperative Brain Function

Effect of Extended Window Thrombectomy on Acute Cerebral Infarction and Granulocyte Colony-Stimulating Factor Expression and Postoperative Brain Function

Xiuli Wang1, Cuilan Hu2 and Sen Ye3*

1Internal Medicine, Jinan Second People’s Hospital, Jinan, 250022, China
2Pharmacy Department, Jiyang People’s Hospital of Jinan, Jinan, 251400, China
3Medical Records Department, Jinan Central Hospital, Jinan, 250013, China
 
* Corresponding author: yesen770138@163.com

ABSTRACT

The aim of this study was to investigate the relationship between extended time window thrombectomy on acute cerebral infarction and granulocyte colony-stimulating factor (GCSF) expression, postoperative brain function. Eighty SD rats were randomly divided into 4 groups: control group, infarction group, 4.5h thrombolysis group and 6h thrombolysis group. The postoperative body weight loss rate and neurological function change of each group were observed by body weight test and neurological function scores. The infarct volume and microvessel density of each group were detected by TTC staining and immunohistochemistry. The effects of thrombectomy on brain wave fluctuation and GCSF in rats at different time points were measured according to electroencephalogram and RT-PCR. We found that the neurological function scores of rats decreased with the prolongation of thrombectomy time, and the scores of neurological function were lower in the 4.5h thrombolysis group than in the 6h thrombolysis group at the same time point. At the same time, the infarct volume of rats decreased in both 4.5h thrombolysis group and 6h thrombolysis group. On the 3rd and 7th postoperatively, compared with the acute infarction group, 4.5h thrombolysis group and 6h thrombolysis group showed increased microvessel density which grew gradually over time, while brain waves tended to flatten. RT-PCR results showed that the infarction group, 4.5h thrombolysis group and 6h thrombolysis group had higher GCSF in brain tissue than the normal group, and both reached the lowest peak on 3d and increased on 7d to a level higher than 1d. At the same time, 6h thrombolysis group had lower mRNA expression of GCSF in the brain tissue than 4.5h thrombolysis group on 1d, 3d and 7d. Extended time window thrombectomy on acute cerebral infarction can promote brain function repair and increase the expression of GCSF in brain tissue.

 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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