Submit or Track your Manuscript LOG-IN

Cytotoxicity and Molecular Docking Studies of a Novel Enaminone and its Cadmium (II) Complex

Cytotoxicity and Molecular Docking Studies of a Novel Enaminone and its Cadmium (II) Complex

Rahila Huma1,2, Tariq Mahmud1,*, Rubina Munir2, Sana Javaid Awan3,Kiran Iftikhar4 and Mufakkira-Tul-Islam5

1Institute of Chemistry, University of the Punjab, Lahore-54590
2Department of Chemistry, Kinnaird College for Women, Lahore
3The University of Lahore, Lahore
4Department of Chemistry, University of Gujrat (UOG), Gujrat
5Department of Chemistry, Lahore College for Women University, Lahore

*      Corresponding author: tariqm06@yahoo.co.uk

 

ABSTRACT

The anti-cancerous potential of novel Enaminone and its Cadmium complex was estimated by measuring its cytotoxicity for human breast cancer cell line (MCF-7). Both compounds PFA and PFA-Cd were prepared and subsequently characterized by FTIR, ICP-AES, UV-Vis, TGA, 1H NMR, 13C NMR and FAB-MS. The results were in great consistency with the structures of the both compounds. Furthermore, the ligand and its metal complex were screened for their cytotoxicity against human cancer cell lines. It was found that the compound PFA was more active anti-cancerous agent as compared to PFA-Cd. Molecular Docking studies were carried out to found the predominate binding mode of synthesized compound in the vicinity of double helical DNA structure.
 

To share on other social networks, click on P-share. What are these?

Pakistan Journal of Zoology

June

Vol. 51, Iss. 3, Pages 801-1202

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe