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Cytokines and Performance Analysis of Broiler Chickens Challenged with Avian Pathogenic E.coli After Administration of Various Immune modulatory Agents

Cytokines and Performance Analysis of Broiler Chickens Challenged with Avian Pathogenic E.coli After Administration of Various Immune modulatory Agents

Ahmed H. Abed1, Ahmed Orabi2*, Wafaa Hassan3, , Enas Hammad4 , Ghada Gaber5 

1Bacteriology, Mycology and Immunology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt, 62511; 2Microbiology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt, 11221; 3Chef Researcher of Poultry Diseases and The Director of Reference Lab for Veterinary Quality Control of Poultry Production, Egypt; 4Researcher in Poultry Diseases Department, Mansoura Lab Animal Health Research Institute, Arc, Egypt; 5Research Assistant of Reference Lab for Veterinary Quality Control of Poultry Production, Egypt.

*Correspondence | Ahmed Orabi, Microbiology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt, 11221; Email: orabi.vet@cu.edu.eg 

ABSTRACT

Avian colisepticemia is the most common bacterial disease in poultry, and it costs the industry a lot of money. This study shows that some immune modulatory substances such as lectins, probiotics, and essential oils have a unique immune-potentiating effect on broiler chickens’ immunity challenged with E. coli. One hundred and twenty broiler chicks were separated into eight equal groups in an in vitro experiment (15 birds for each group). A negative control group was the first group. There were 3 groupings were given immune modulatory agents (lectins, probiotic, and essential oil) for five days without being challenged; Immune modulatory agents were given to the remaining three groups, who were also infected with E. coli O78, and one group act as an E. coli O78 challenged group. The obtained results showed improvement of the growth performance of the three groups administrated immune modulatory agents without challenge. The level of IL-4 gene expression was increased, and it effectively reduced INFG, and IL-6 mRNA gens expression.

Keywords | Broiler chickens, Cytokines, E. coli, Essential oils, Lectins, Performance, Probiotics. 

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Advances in Animal and Veterinary Sciences

1

Vol. 11, Iss. 1, Pages 1-188

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