Critical Update for the Treatment of Anemia by using Advanced Genome Editing Crispr Cas Technology
Ghulam Akbar1*, Ali Ahmad2, Neha Arooj1, Muhammad Anjum Zia1, Aamna Rafique1, Sania Riasat1, Mohsin Raza1, Mahpara Qamar1, Shahneela Nusrat1 and Shakila Hanif1
ABSTRACT
Anemia is the condition which results in formation of unhealthy red blood cells which results lack of oxygen supply towards tissues of body. It is common and worldwide problem that associates with all ages like pregnant women, children and aged people. Anemia associated with numerous infectious and continual problems such as persistent kidney disease, cancer, ischemic heart ailment and inflammatory bowel disorder. However, with the development in generation at genome editing level have made feasible to accurate mutations in human genome. A site oriented specific break in double stranded DNA is induced by CRISPR/Cas9, whereas different oligonucleotides are provided to make accurate DNA template for genome correction. It is of importance to knowledge about types of CRISPR to treat anemia. Cas 9 showed one of best gene editing reactions than others. Recent data gives authentic applications of CRISPR use in anemia which provides potential for usage of gene editing technique for different types of anemia. In evaluation we defined currently developed genome editing device update used for the remedy of anemia, its mechanism of movement and sickle cellular mutation corrections.
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