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Computational Pharmacophore Modelling of 5-HT2a and D2 Receptor Inhibitors of Schizophrenia

Computational Pharmacophore Modelling of 5-HT2a and D2 Receptor Inhibitors of Schizophrenia

Rida Zainab1, Sana Elahi1, Afshan Kaleem2,*, Daniel C. Hoessli3, Mehwish Iqtedar2, Roheena Abdullah2, Faiza Saleem2, Shanza Khan1, Anusha Ijaz1, Shagufta Naz2 and Abdul R. Shakoori4,5,*

1Department of Biotechnology, Kinnaird College for Women, Lahore
2 Department of Biotechnology, Lahore College for Women University, Lahore
3 Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi
4School of Biological Sciences, University of the Punjab, Quaid-e-Azam Campus Lahore
5Department of Biochemistry, Faculty of Life Sciences, University of Central Punjab, Lahore

*      Corresponding authors: arshaksbs@yahoo.com; fshan.kaleem@lcwu.edu.pk

 

Fig. 1.

Pharmacophore model of Blonanserin (A), Clozapine (B) and Iloperidone (C).

Fig. 2.

Pharmacophore model of Lurasidone (A), Melperone (B) and Mosapramine (C).

Fig. 3.

Pharmacophore model of Olanzapine (A), Paliperidone (B) and Perospirone (C).

Fig. 4.

Pharmacophore model of Quetiapine (A), Risperidone (B) and Tiospirone (C).

Fig. 5.

Pharmacophore model of Ziprasidone (A), Zotepine (B) and Fluperlapine (C).

Fig. 6.

Combined Pharmacophore model of all the 15 ligands.

Fig. 7.

Minimum and maximum distance ranges among all the features.

Pakistan Journal of Zoology

December

Vol. 50, Iss. 6, Pages 1999-2398

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