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Compatibility of Intravenous Fat Emulsion and Antibiotics in Secondary Piggyback Transfusion

Compatibility of Intravenous Fat Emulsion and Antibiotics in Secondary Piggyback Transfusion

Nina Chen1, Shuang Xu2, Juanjuan Lin1* and Moslem Lari Najafi3

1Department of Pediatrics, Xiangyang NO.1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, China
2Department of Obstetrics and Gynecology, Xiangyang NO.1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, China
3Pharmaceutical Sciences and Cosmetic Producs Research Center, Kerman University of Medical Sciences, Kerman, Iran
 
Nina Chen and Shuang Xu contributed equally to this article. 
 
* Corresponding author: linjuliar@163.com

ABSTRACT

According to the change of fat particle size distribution, this study aimed explore the compatibility of fat emulsion and antibiotics in piggyback infusion. In this study 5% glucose solution, fat emulsion and mixture containing 25 kinds of antibiotics were prepared by the proportion suitable for piggyback infusion (33:10:40). The number of fine particles was analyzed by automatic particle counter. According to results, even 24 h after preparation, 12 β-lactam antibiotics, clindamycin phosphate, teicoplanin, trimethoprim/ sulfamethoxazole and micafungin sodium did not change significantly. The particle size of the mixture containing vancomycin hydrochloride, levofloxacin hydrate, metronidazole and fluconazole increased gradually. The particle size of fosfomycin sodium in the mixture containing gentamicin sulfate, abacain sulfate, minocycline hydrochloride, ciprofloxacin and/ or ciprofloxacin also changed significantly after preparation. We concluded the particle size changes of some drugs indicate that these drugs may cause changes in fat particle size during administration. Therefore, these antibiotic preparations should not be administered in conjunction with fat emulsion.

 

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Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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