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Comparative Effect of Propofol and Thiopentone Sodium in Sheep Sedated with Xylazine Hydrochloride

Comparative Effect of Propofol and Thiopentone Sodium in Sheep Sedated with Xylazine Hydrochloride

Rahim Dad Brohi1,*, Amir Bukhsh Kalhoro1, Allah Bux Kachiwal1, Illahi Bux Kalhoro1, Dildar Hussain Kalhoro1, Sarfaraz Ahmed2, Farhan Anwar Khan3, Hira Sajjad Talpur1, Zia-ur-Rehman1 and Dinesh Bhattaria4

1Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
2National Center of Meat Quality and Safety Control, College of Food Science and Engineering, Nanjing Agricultural University, Nanjing, China
3Department of Animal Health, Faculty of Animal Husbandry & Veterinary Sciences, The University of Agriculture, Peshawar
4Department of Veterinary Gynecology and Obstetrics, Institute of Agriculture and Animal Science, Tribhuvan University, Nepal

*      Corresponding author:



Combination effect of propofol (6 mg/kg) and thiopentone sodium (8 mg/kg) administrated intravenously after premedication with xylazine hydrochloride (0.02 mg/kg) has been studied on six healthy female sheep using a crossover design. During xylazine therapy the pulse rate was significantly (P<0.01) decreased, but respiratory rate remained unchanged. The administration of anesthesia on the other hand caused a significant (P<0.01) increase in the pulse rate and a significant (P<0.01) decrease in the respiratory rate. The body temperature decreased (P<0.01) with all the three anesthetic regimens. The means of safe induction of anesthesia (propofol, 14.00 ± 0.2582; and thiopentone sodium, 14.83 ± 0.1667 seconds) and duration of anesthesia (thiopentone sodium, 14.50 ± 0.2236 and propofol, 13.22 ±0.1014 min), and a full recovery from anaesthesia (thiopentone sodium, 13.67 ± 0.4216; and propofol, 12.45 ± 0.2432 min) were differed from one another. Comparing the results of this study, it is concluded that the intravenous therapy of propofol caused a smooth quality of induction and recovery from anesthesia. Based on the measured parameters it also concludes that propofol is preferably recommended as safe therapy than thiopentone sodium for the surgical operations. Moreover, anesthetic regimens can safely be used in sheep in field as well as hospital conditions.

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Pakistan Journal of Zoology


Vol. 54, Iss. 1, Pages 1-501


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