Combination effect of propofol (6 mg/kg) and thiopentone sodium (8 mg/kg) administrated intravenously after premedication with xylazine hydrochloride (0.02 mg/kg) has been studied on six healthy female sheep using a crossover design. During xylazine therapy the pulse rate was significantly (P<0.01) decreased, but respiratory rate remained unchanged. The administration of anesthesia on the other hand caused a significant (P<0.01) increase in the pulse rate and a significant (P<0.01) decrease in the respiratory rate. The body temperature decreased (P<0.01) with all the three anesthetic regimens. The means of safe induction of anesthesia (propofol, 14.00 ± 0.2582; and thiopentone sodium, 14.83 ± 0.1667 seconds) and duration of anesthesia (thiopentone sodium, 14.50 ± 0.2236 and propofol, 13.22 ±0.1014 min), and a full recovery from anaesthesia (thiopentone sodium, 13.67 ± 0.4216; and propofol, 12.45 ± 0.2432 min) were differed from one another. Comparing the results of this study, it is concluded that the intravenous therapy of propofol caused a smooth quality of induction and recovery from anesthesia. Based on the measured parameters it also concludes that propofol is preferably recommended as safe therapy than thiopentone sodium for the surgical operations. Moreover, anesthetic regimens can safely be used in sheep in field as well as hospital conditions.