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Reporter Classical Swine Fever Virus: A Powerful Tool to Study Virus Biology

Reporter Classical Swine Fever Virus: A Powerful Tool to Study Virus Biology

Yongfeng Li, Mo Zhou, Xiao Wang, Libao Xie, Hua-Ji Qiu*

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.

ABSTRACT

Classical swine fever virus (CSFV) is generally a noncytopathogenic virus in cell cultures. The development of reporter CSFV has provided an excellent option to directly detect viral replication without the use of secondary labeling. This mini-review discusses the applications of reporter CSFV in the study of CSFV biology, including efficiently screening the antivirals against CSFV and viral receptors, conveniently tracking the viral proteins in live cells as well as improving diagnostic methods and vaccines for classical swine fever.

 

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Hosts and Viruses

June

Vol.6, Iss.3, Pages 42-84

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