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Chemoprotective Effect of Daphnetin against Benzene Induced Leukemia Cancer via Alteration of CYP2E1

Chemoprotective Effect of Daphnetin against Benzene Induced Leukemia Cancer via Alteration of CYP2E1

Junling Liu, Chen Sun, Qiao Yu, Yanzhi Liang, Shanshan Lin and Meng Tian*

Department of Hematology, Qingdao Hospital of  Traditional Chinese Medicine, Shibei District, No. 4 Renmin Road, Qingdao City, Shandong Province, 266033, China
 
* Corresponding author: tianm8377@sina.com

Fig. 1.

Effect of daphnetin on various haematological paramenters in benzene induced leukaemic rats. A, HCT; B, WBC; C, RBC; D, Hb; E, MCV; F, MCH; G, MCHC; H, PLT. The data are shown as mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the benzene induced leukaemia rats.

Fig. 2.

Effect of daphnetin on differential of leukocytic count of benzene induced leukaemic rats. A, LYM; B, Neutrophils; C, Blast; D, Monocytes; E, Eosinophils; F, Basophils. The data are shown as mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the benzene induced leukaemia rats.

Fig. 3.

Effect of daphnetin on antioxidant parameters in serum of benzene induced leukaemic rats. A, MDA; B, GSH; C, 8-OhdG. The data are shown as mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the benzene induced leukaemia rats.

Fig. 4.

Effect of daphnetin on antioxidant parameters in liver tissue of benzene induced leukaemic rats. A, MDA; B, GSH. The data are shown as mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the benzene induced leukaemia rats.

Fig. 5.

Effect of daphnetin on proinflammatory cytokines of benzene induced leukaemic rats. A, IL-1β; B, IL-6; C, TNF-α. The data are shown as mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the benzene induced leukaemia rats.

Fig. 7.

Effect of daphnetin on the level of CyP2E1 mRNA of benzene induced leukaemic rats. The data are shown as mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the benzene induced leukaemic rats.

Fig. 6.

Effect of daphnetin on cytochrome P450E1 of benzene induced leukaemic rats. The data are shown as mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the benzene induced leukaemia rats.

Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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