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Changes of Colon Flora and Antitoxic Effect Induced by Zearalenone in Mice

Changes of Colon Flora and Antitoxic Effect Induced by Zearalenone in Mice

Jing Zhang1,2, Xin Wang2, Yun Zhao2, Yongcheng Jin2, Yongfeng Zhou2, Junmei Wang2, Yurong Fu2, Rui Wang2, Ruihua Li2, Hengtong Fang2 and Hao Yu2,*

1Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130062, China
2College of Animal Science, Jilin University, Changchun 130062, China
 
Hengtong Fang and Hao Yu contributed equally to this article.

*      Corresponding author: yu_hao@jlu.edu.cn

Fig. 1.

The effect of ZEA on the intestinal mucosal morphology of the colon in BALB/C mice. A: The colon of the CON group. B: The colon of the ZEA group. C: The area of intestinal cavity. **: P value<0.01.

Fig. 2.

Effect of ZEA on the intestinal microflora. (A), comparison of OTU. (B), rarefaction curves based on the observed species values. (C), relative abundance of different bacterial phylum. (D), relative abundance of different bacterial genus.

Fig. 3.

Changes in the immune gene expression in the colonic mucosa of the mice. All the data are expressed as the means ± SEM. *: P value<0.05, **: P value<0.01.

Fig. 4.

(A), Changes in the sIgA levels in the colonic faeces. (B), Changes in the cytokines in the colon. All the data are expressed as the means ± SEM. **: P value<0.01, ***: P value<0.001.

Fig. 5.

Schematic diagram of ZEA acting on colonic mucosa.

Pakistan Journal of Zoology

October

Vol. 52, Iss. 5, Pages 1631-2026

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