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Biochemical Profiling of Arsenic Trioxide-Induced Impaired Carbohydrate Metabolism and its Therapeutic Intervention via Modulation of Metabolic Pathways

Biochemical Profiling of Arsenic Trioxide-Induced Impaired Carbohydrate Metabolism and its Therapeutic Intervention via Modulation of Metabolic Pathways

Muhammad Sajid Hamid Akash1*, Hina Sharif1, Kanwal Rehman2, Sumbal Rasheed1 and Shagufta Kamal3

1Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
2Department of Pharmacy, The Women University, Multan, Pakistan.
3Department of Biochemistry, Government College University, Faisalabad, Pakistan.
 
* Corresponding author: sajidakash@gmail.com

Fig. 1.
Effect of ATO on serum insulin (A), insulin resistance (B), bloood glucose level (C) and HbA1c level (D). Significance was estimated by Bonferroni post-test using one way ANOVA. * represents P < 0.05, ** represents P < 0.01 and ns represents non-significant when compared with NC group. ATO, arsenic trioxide group; HbA1c, hemoglobin A1c; MF, metformin group; NC, normal control group; RSV, resveratrol group.
Fig. 2.
Effect of ATO on activities of α-amylase (A), α-glucosidase (B), hexokinase (C) and G6PC (D). 
For statistical details and abbreviations, see Figure 1.
Fig. 3.

Arsenic concentration in the liver sample is detected by HG-AAS. For statistical details and abbreviations, see Figure 1. *** represents P < 0.001 when compared with NC group. As, arsenic; HG-AAS, hydride generation atomic absorption spectroscopy. 

Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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