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Baohuoside I Inhibits Benzo(a)Pyrene-Induced Metastasis in A549 Lung Cancer Cells by Modulating STAT3 and EMT

Baohuoside I Inhibits Benzo(a)Pyrene-Induced Metastasis in A549 Lung Cancer Cells by Modulating STAT3 and EMT

Muhammad Khan1,*, Amara Maryam2, Hafiz Abdullah Shakir1, Javed Iqbal Qazi1 and Yongming Li3,*

1Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
2College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning116044, P.R. China
3Institute of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China

*      Corresponding authors: khan_zoologist@ymail.com; liyongming1979@sina.com

 

ABSTRACT

Benzo(a)pyrene (BaP), a major component of cigarette smoke, has been found to be a potent human carcinogen. Recently, it has been shown to induce lung cancer metastasis. In the present study, we found for the first time that Baohuoside I (BHS-1), a natural flavonol glycoside inhibits BaP-induced A549 lung cancer metastasis by modulating the expressions of p-STAT3, COX-2, MMP-2, MMP-9, E-cadherin and N-cadherin. Moreover, we found that chronic BaP exposure promoted migration without enhancing the proliferation of cells and BHS-I was equally toxic to both BaP-treated and untreated A549 cells. Taken together, the data of present study indicate that BHS-I not only inhibits metastasis but also induces cell death in BaP-treated A549 cells. Therefore, BHS-I may become a potential lead compound for treatment of lung adenocarcinoma.
 

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Pakistan Journal of Zoology

December

Vol. 50, Iss. 6, Pages 1999-2398

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