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Associations of Diplotypes of Vldlr Gene with Egg Production Traits in Laiwu Black Chickens

Associations of Diplotypes of Vldlr Gene with Egg Production Traits in Laiwu Black Chickens

Yan Zhou1,2, Hai Xia Han1,2, Qiu Xia Lei1,2, Jin Bo Gao1,2, Wei Liu1,2, Fu Wei Li1,2, Jie Liu1,2 and Ding Guo Cao1,2*

1Institute of Poultry Science, Academy of Agricultural Sciences of Shandong Province, Jinan, Shandong, China
2Poultry Breeding Engineering Technology Center of Shandong Province, Jinan, Shandong, China
 
Yan Zhou and Hai Xia Han contributed equally to this study.

*      Corresponding author: jqsyzs@163.com

ABSTRACT

Very low density lipoprotein receptor (VLDLR) is of vital importance for egg production in mediating the synthesis of yolk protein precursors. To better understand the effects of VLDLR on reproduction in chickens, the haplotypes and diplotypes based on three genetic mutations (NC_006127.2:g.8467G>A, NC_006127.2:g.12321G>A and NC_006127.2:g.13876A>G) were constructed, and the associations of diplotypes with reproduction traits were assessed, their effects on gene expression were evaluated also. As a result, three haplotypes H1 (G-G-A), H2 (G-G-G) and H3 (A-A-G) were obtained, H1 was the main haplotype with a frequency of 91.75%. The correlation analysis showed that diplotypes (H1H1, H2H2 and H3H3) were significantly associated with egg production at age of 40W (E40) (P=0.0342) and egg production at age of 43W (E43) (P=0.0184). The egg production at age of 38W (E38), E40 and E43 of H2H2 chickens were all higher than those of the H1H1 and H3H3 chickens. Compared with H1H1 and H3H3 chickens, the highest mRNA levels of VLDLR were found in ovary, 6 mm - 8 mm follicles and 4 mm follicles from H2H2 chickens, and significant difference compared with those of H3H3 chickens (P<0.01). These findings suggest that VLDLR could be considered a candidate gene for egg production in chickens.
 

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Pakistan Journal of Zoology

October

Vol. 52, Iss. 5, Pages 1631-2026

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