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Association of Loci 6q25.1/rs6922269 and 9p21.3/rs1333049 with Risk of Coronary Heart Disease in Patients Visiting Hospitals of Gujranwala and Lahore Divisions

Association of Loci 6q25.1/rs6922269 and 9p21.3/rs1333049 with Risk of Coronary Heart Disease in Patients Visiting Hospitals of Gujranwala and Lahore Divisions

Iqra Arooj1,* and Shahida Hasnain2

1Department of Microbiology and Molecular Genetics, The Women University, Multan
2Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore

*     Corresponding author: iqra.6051@wum.edu.pk

 

ABSTRACT

Cardiovascular diseases such as coronary heart disease (CHD) are a growing health concern in developing and under-developed countries. Some of their risk factors are smoking, obesity, diabetes, family history, high blood pressure etc. Previous genome wide association studies have identified association of large number of loci with risk of CHD in different populations. The purpose of this study was to determine the association of 6q25.1/rs6922269 and 9p21.3/rs1333049 loci with risk of CHD in a population of Punjab province of Pakistan. A total of 645 subjects were included in this study of which 435 were patients visiting hospitals of Lahore and Gujranwala districts. All the subjects were genotyped by allele-specific PCR. It was observed that the loci 6q25.1/rs6922269 and 9p21.3/rs1333049 were significantly associated with risk of CHD in this population (P=0.001 and 0.012, respectively).
 

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Pakistan Journal of Zoology

December

Vol. 50, Iss. 6, Pages 1999-2398

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