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Aptamers and SELEX: Tools for the Development of Transformative Molecular Recognition Technology

Aptamers and SELEX: Tools for the Development of Transformative Molecular Recognition Technology

Maureen McKeague1, Maria C. DeRosa2*

1Department of Bioengineering, Stanford University, 443 Via Ortega, MC 4245, Stanford, CA, USA,94305; 2Carleton University, Department of Chemistry and Institute of Biochemistry, 225 Steacie Building 1125 Colonel By Drive Ottawa, ON K1S 5B6, Canada

E-mail | maria_derosa@carleton.ca

ABSTRACT

Aptamers, single stranded nucleic acid-based molecular recognition elements, are generated through an in vitro evolution process called SELEX. The selection of aptamers with optimal specificity and high affinity remains a challenge, leading to the recent emergence of elegant new approaches and tools for SELEX. In this commentary, we discuss recent advancements in the selection of aptamers.

 

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Aptamers and Synthetic Antibodies

June

Vol.2, Iss.1, Page 1-35

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