Submit or Track your Manuscript LOG-IN

Anti-Cancerous and Anti-Inflammatory Activities of some Novel Schiff Bases Derived from 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N- [4-(hydrazinecarbonyl)phenyl]acetamide

Anti-Cancerous and Anti-Inflammatory Activities of some Novel Schiff Bases Derived from 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N- [4-(hydrazinecarbonyl)phenyl]acetamide

Aqsa Gulzar1, Tariq Mahmud1,*, Rubina Munir2 and Asma Anjum3

1Institute of Chemistry, University of the Punjab, Lahore 54590
2Department of Chemistry, Kinnaird College for Women, Lahore
3Division of Science and Technology, University of Education, Lahore 

*  Corresponding author: tariqm06@yahoo.co.uk

 

ABSTRACT

The anti-cancerous and anti-inflammatory potential of two novel Schiff bases was carried out by MTT - colorimetric protocol on HeLa cells (cervical disease) and Luminol-improved chemiluminescence assay, respectively. The novel Schiff bases 4a and 4b have been synthesized by the reaction of 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide with 3-nitro and 4-nitrobenzaldehyde. Characterization of the synthesized compounds was done by using various spectroscopic techniques namely FTIR, proton and carbon-13 NMR, Mass spectrometry and elemental analysis. The results were in great consistency with the structures of the synthesized compounds and confirmed the formation of the targeted compounds. It was found that the compound 4a was potentially anti-inflammatory active while the compound 4b was found more active anti-cancerous agent as compared to 4a.
 

To share on other social networks, click on P-share. What are these?

Pakistan Journal of Zoology

December

Vol. 50, Iss. 6, Pages 1999-2398

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe