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A New Technique for Development of Rabbit Ear Keloid Model

A New Technique for Development of Rabbit Ear Keloid Model

Abdul Mannan Babar1* and Abdul Hannan Nagi2

1Department of Surgery, Postgraduate Medical Institute, Ameeruddin Medical College, Lahore General Hospital, Lahore, Pakistan
2Department of Pathology, Experimental Research Laboratory, University of Health Sciences, Lahore, Pakistan

* Corresponding author: ambabar@gmail.com

ABSTRACT

Keloids and hypertrophic scars are an exaggeration of fibroplasia in dermal repair. Keloids are found solely in humankind, and not in animals. Thus far no practicable animal model of Keloid has been made. Recently a prototype rabbit ear keloid model has been produced by the authors by giving Transforming Growth Factor Beta 1 injection, and then skin punch excision on rabbit ear. In the present follow-up study consisting of eight refind techniques, best Keloid was produced by the technique where Transforming Growth Factor Beta 1 injection was followed by ventral skin, ventral perichondrium, cartilage, and dorsal perichondrium punch excision, leaving behind only dorsal skin.

 

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Pakistan Journal of Zoology

December

Vol. 51, Iss. 6, Pages 1999-2399

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