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A Murine Model of Femoral Artery Injury: Tricks of the Trade

A Murine Model of Femoral Artery Injury: Tricks of the Trade

Jixue Hou1,2, Xueling Chen3, Jing Wang4, Hongwei Zhang2, Yu Xi2, Jie Xia2, Xinyu Peng2,* and Xiangwei Wu2,5*

1Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
2Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832008, China
3Department of Immunology, School of Medicine, Shihezi University, Shihezi, Xinjiang 832002, China
4Out-patient department, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832008, China
5Laboratory of Translational Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang 832008, China

* Corresponding author: wxwshz@126.com

ABSTRACT

Mammals is a powerful tool to study pathophysiologic process of cardiovascular disease, but for a long time it is just limited to large animals, like pigs, rabbits, and big rats. The mice with reproduction fast cycle, lower costing, and close to human genes, can be showed about some phenomenon quickly, also more easy to form model of atherosclerosis. Thus, a mouse model of vascular injury is vitally important for researching the pathophysiological mechanisms to restenosis after percutaneous transluminal coronary angioplasty (PTCA) as well as translational approaches. In this Experiment, we established a unique murine model of femoral artery injury through a home-made wire. The mouse model of vascular injury may be used to explore the molecular mechanism of post-angioplasty restenosis with lowest costing.

 

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Pakistan Journal of Zoology (Associated Journals)

December

Vol. 49, Iss. 5, Pages 1937-2341

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