Studies on Haematological and some Serum Biochemical Changes by Oral Administration of Gossypol from Cotton Seed Cake in Rabbits
Studies on Haematological and some Serum Biochemical Changes by Oral Administration of Gossypol from Cotton Seed Cake in Rabbits
Altaf Mahmood1*, Muhammad Athar Khan2, Saima Parveen3, Tanveer Hussain4 and Ayesha Azad5
ABSTRACT
In present experimental study, haematological and some serum biochemical alterations were explored in six months old commercially raised eight female rabbits after oral administration of gossypol. Cotton seed cake with 0.25% free gossypol concentration was daily given to each rabbit at the rate of 4 grams per kg live weight for entire experiment period of 60 days. Analysis of fortnightly collected blood specimens revealed significantly (p <0.05) decreased hematocrit, total red blood cell count, mean corpuscular volume, haemoglobin concentration and inorganic phosphorous level of serum whereas significantly (p < 0.05) decreased mean corpuscular haemoglobin, red cell distribution width, mean corpuscular haemoglobin concentration, total white cell count, monocytes and lymphocytes. The level of serum calcium and granulocytes exhibited non significant (p > 0.05) difference. It was concluded that gossypol exposure induces anaemia, microsytosis and hypophosphetaemia.
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